The Thyroxine Binding Globulin (TBG) test is a blood test used to measure the level of TBG, a protein responsible for transporting thyroid hormones (T3 and T4) in the bloodstream.
Most thyroid hormones are bound to proteins like TBG, and only a small fraction remains free and biologically active. Abnormal TBG levels can affect total thyroid hormone measurements without altering actual thyroid function.
This test is useful in evaluating unexplained abnormalities in total T3 and T4 levels, and in conditions such as pregnancy, liver disease, or genetic variations affecting TBG levels. It helps differentiate between true thyroid dysfunction and altered protein binding.
The purpose of this test is to